Methanol is a transportation fuel, and direct fuel for fuel cell. It is commercially produced via synthesis gas process. Several technology of methanol synthesis has already being developed, mostly in gas phase and heterogeneous system at a temperature of 400˚C and pressure of range 300-1000 bar. Recent development for methanol synthesis technology is known as liquid phase methanol, but still, it involves heterogeneous system. To render an alternative route to produce methanol, a homogeneous system with milder operating conditions is studied. This new one-pot reaction was developed and tested by using methyl acetate and calcium hydroxide as the raw materials. The liquid reactants were reacted in a semi-batch reactor at milder operating conditions of temperature less than 60°C and at atmospheric pressure. The process is known as saponification and it was tested to find the best combination of operating conditions that can produce the most yield of methanol at a maximum conversion of methyl acetate. In designing the experiment, Taguchi robust design method with L16 orthogonal array was implemented to optimize experimental conditions for the production of liquid methanol. Reactor type, reactor volume, flow rate of reactants, reactants’ concentrations and temperature were chosen as significant parameters in designing the experiment.It is found that reactants’ concentrations were the most influencing parameters that affect the production of methanol, with 38.15% contribution from methyl acetate and 25.39% from calcium hydroxide. The optimum yield was 32.2%.